Consider the following statements regarding human blood clotting: 1. Fibrinogen is converted into insoluble fibrin threads by the action of the enzyme thrombin. 2. Vitamin K is essential for the hepatic synthesis of several clotting factors including prothrombin. Which of the statements given above is/are correct?

💡 Solution & Explanation

Blood coagulation involves a complex cascade where soluble plasma protein fibrinogen is cleaved by active thrombin into insoluble fibrin strands that entrap blood cells to form a stable clot, while vitamin K is required by the liver to synthesize functional prothrombin and other coagulation factors. Incorrect options fail to acknowledge both enzymatic conversion and vitamin cofactor requirements. Hemophilia is an inherited bleeding disorder caused by the deficiency of specific clotting factors in the cascade.