Which immunoglobulin antibody is primarily involved in mediating allergic reactions and defense against parasitic helminth infections?

💡 Solution & Explanation

Immunoglobulin E binds specifically to high-affinity Fc epsilon receptors on mast cells and basophils, which triggers the degranulation and release of inflammatory mediators like histamine during hypersensitivity reactions. Other antibody classes handle different immune tasks, such as mucosal defense or neutralization. This antibody type also plays a crucial evolutionary role in orchestrating immune responses against parasitic helminths.