Which organ in the human body is responsible for the synthesis of urea from ammonia via the urea cycle?

💡 Solution & Explanation

The liver is the principal metabolic organ responsible for converting toxic ammonia, generated through amino acid deamination, into relatively harmless urea via the hepatic urea cycle. Kidneys subsequently filter this urea out of the bloodstream for excretion in urine, but they do not synthesize it in significant quantities.